Atomistry » Praseodymium » PDB 1k0z-6b41 » 5sjt
Atomistry »
  Praseodymium »
    PDB 1k0z-6b41 »
      5sjt »

Praseodymium in PDB 5sjt: Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide

Enzymatic activity of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide

All present enzymatic activity of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide:
3.1.4.17;

Protein crystallography data

The structure of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide, PDB code: 5sjt was solved by C.Joseph, J.Benz, A.Flohr, J.Peters, M.G.Rudolph, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.87 / 2.10
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 134.64, 134.64, 235, 90, 90, 120
R / Rfree (%) 16 / 17.9

Other elements in 5sjt:

The structure of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide also contains other interesting chemical elements:

Magnesium (Mg) 4 atoms
Zinc (Zn) 4 atoms
Chlorine (Cl) 1 atom

Praseodymium Binding Sites:

The binding sites of Praseodymium atom in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide (pdb code 5sjt). This binding sites where shown within 5.0 Angstroms radius around Praseodymium atom.
In total 8 binding sites of Praseodymium where determined in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide, PDB code: 5sjt:
Jump to Praseodymium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Praseodymium binding site 1 out of 8 in 5sjt

Go back to Praseodymium Binding Sites List in 5sjt
Praseodymium binding site 1 out of 8 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide


Mono view


Stereo pair view

A full contact list of Praseodymium with other atoms in the Pr binding site number 1 of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pr803

b:56.2
occ:1.00
 O B:HOH901 2.0 33.4 1.0
O B:HOH1069 2.5 36.5 1.0
O B:HOH1055 2.9 39.9 1.0
OD2 B:ASP757 3.0 47.2 1.0
O D:HOH1010 3.0 61.9 1.0
CG B:ASP757 3.3 36.5 1.0
OD1 B:ASP757 3.4 43.9 1.0
NZ B:LYS753 4.1 46.1 1.0
O B:HOH906 4.3 43.4 1.0
CB B:ASP757 4.5 35.8 1.0
CG D:GLU647 4.9 63.8 1.0
OE1 D:GLU647 4.9 65.8 1.0

Praseodymium binding site 2 out of 8 in 5sjt

Go back to Praseodymium Binding Sites List in 5sjt
Praseodymium binding site 2 out of 8 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide


Mono view


Stereo pair view

A full contact list of Praseodymium with other atoms in the Pr binding site number 2 of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pr804

b:62.9
occ:1.00
 O B:HOH1075 2.7 46.4 1.0
O B:HOH943 2.9 40.6 1.0
O B:HOH1034 3.2 46.1 1.0
O B:HOH940 3.8 46.7 1.0
OE2 B:GLU763 4.4 41.6 1.0
OE1 B:GLU763 4.8 43.7 1.0

Praseodymium binding site 3 out of 8 in 5sjt

Go back to Praseodymium Binding Sites List in 5sjt
Praseodymium binding site 3 out of 8 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide


Mono view


Stereo pair view

A full contact list of Praseodymium with other atoms in the Pr binding site number 3 of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pr805

b:71.8
occ:1.00
 O B:HOH903 2.4 37.7 1.0
OE2 B:GLU606 2.5 45.4 1.0
OE1 B:GLU606 3.1 54.8 1.0
CD B:GLU606 3.1 48.3 1.0
PR B:PR807 3.8 76.8 1.0
O B:HOH967 4.6 50.4 1.0
CG B:GLU606 4.6 46.7 1.0

Praseodymium binding site 4 out of 8 in 5sjt

Go back to Praseodymium Binding Sites List in 5sjt
Praseodymium binding site 4 out of 8 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide


Mono view


Stereo pair view

A full contact list of Praseodymium with other atoms in the Pr binding site number 4 of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pr806

b:74.2
occ:1.00
 O B:HOH1068 2.3 32.5 1.0
OE1 B:GLU620 3.3 51.4 1.0
OG B:SER617 3.4 49.9 1.0
CD B:GLU620 4.5 54.5 1.0
CB B:SER617 4.6 48.7 1.0
CA B:SER617 4.8 45.5 1.0

Praseodymium binding site 5 out of 8 in 5sjt

Go back to Praseodymium Binding Sites List in 5sjt
Praseodymium binding site 5 out of 8 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide


Mono view


Stereo pair view

A full contact list of Praseodymium with other atoms in the Pr binding site number 5 of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pr807

b:76.8
occ:1.00
 O B:HOH1035 2.5 36.0 1.0
OE1 B:GLU606 2.8 54.8 1.0
CD B:GLU606 3.5 48.3 1.0
PR B:PR805 3.8 71.8 1.0
OE2 B:GLU606 4.0 45.4 1.0
CG B:GLU606 4.4 46.7 1.0
O B:HOH903 4.7 37.7 1.0

Praseodymium binding site 6 out of 8 in 5sjt

Go back to Praseodymium Binding Sites List in 5sjt
Praseodymium binding site 6 out of 8 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide


Mono view


Stereo pair view

A full contact list of Praseodymium with other atoms in the Pr binding site number 6 of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Pr803

b:104.5
occ:0.33
 O C:HOH904 2.2 32.1 1.0
O C:HOH1009 2.4 33.8 1.0
OE2 C:GLU620 3.3 35.5 0.5
OE1 C:GLU620 3.5 41.8 0.5
CD C:GLU620 3.8 36.6 0.5
OE1 C:GLU620 3.9 48.0 0.5
CD C:GLU620 4.9 42.7 0.5
OG C:SER617 5.0 52.7 1.0

Praseodymium binding site 7 out of 8 in 5sjt

Go back to Praseodymium Binding Sites List in 5sjt
Praseodymium binding site 7 out of 8 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide


Mono view


Stereo pair view

A full contact list of Praseodymium with other atoms in the Pr binding site number 7 of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Pr804

b:103.6
occ:0.33
 PR C:PR805 4.0 115.3 0.3
OE2 C:GLU606 4.4 59.0 1.0

Praseodymium binding site 8 out of 8 in 5sjt

Go back to Praseodymium Binding Sites List in 5sjt
Praseodymium binding site 8 out of 8 in the Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide


Mono view


Stereo pair view

A full contact list of Praseodymium with other atoms in the Pr binding site number 8 of Crystal Structure of Human Phosphodiesterase 10 in Complex with 4-N,4- N,2-Trimethyl-3-N-(2-Phenylimidazo[1,2-A]Pyridin-7-Yl)Pyrazole-3,4- Dicarboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Pr805

b:115.3
occ:0.33
 O C:HOH970 2.5 48.5 1.0
OE2 C:GLU606 2.9 59.0 1.0
CD C:GLU606 3.8 51.8 1.0
PR C:PR804 4.0 103.6 0.3
OE1 C:GLU606 4.1 50.9 1.0

Reference:

A.Flohr, D.Schlatter, B.Kuhn, M.G.Rudolph. Crystal Structure of A Human Phosphodiesterase 10 Complex To Be Published.
Page generated: Thu Oct 10 10:28:18 2024

Last articles

Mg in 7M44
Mg in 7M2M
Mg in 7M1T
Mg in 7M13
Mg in 7M1Q
Mg in 7M0Z
Mg in 7M0Y
Mg in 7M0X
Mg in 7M0W
Mg in 7M0E
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy